hSERT WT | hSERT Y95F | |||
---|---|---|---|---|
[3H]5-HT | [3H]DA | [3H]5-HT | [3H]DA | |
5-HT | 1300 ± 220 | 1400 ± 50 | 1100 ± 170 | 850 ± 40 |
DA | 360,000 ± 21,000 | 84,000 ± 7000*** | 59,000 ± 3000 | 11,000 ± 1300*** |
Cocaine | 8000 ± 2000 | 270 ± 20* | 1700 ± 300 | 77 ± 6.0** |
MDMA | 4400 ± 840 | 2700 ± 330* | 3100 ± 430 | 940 ± 110*** |
Paroxetine | 140 ± 42 | 25 ± 12* | 450 ± 120 | 85 ± 40* |
Fluoxetine | 710 ± 200 | 71 ± 19** | 1200 ± 310 | 140 ± 37** |
Citalopram | 89 ± 17 | 16 ± 5.6** | 1200 ± 240 | 92 ± 18*** |
GBR 12935 | 16,000 ± 3000 | 17,000 ± 2700 | 9800 ± 1500 | 8300 ± 1200 |
↵All values are given as nm and represent mean value ± SEM; n = 3–9. Significance levels are indicated for [3H]5-HT versus [3H]DA by the two-tailed t test (*p < 0.05; **p < 0.01; ***p < 0.001).