List of genes that are downregulated by protective doses of MTM (300 nm) and SDK (75 nm), involved in carcinogenesis, and obtained from two networks identified in the microarray analysis: cell cycle and molecular mechanism of cancer
| Gene | Mediate carcinogenesis |
|---|---|
| ADCY3 | + |
| ADCY8 | + |
| ADCY9 | + |
| BMPR1A | + |
| HIF1A | + |
| LRP5 | + |
| LRP6 | + |
| MAP2K4 | + |
| MAPK14 | + |
| NFKBIB | + |
| PIK3C3 | + |
| PRKAG2 | + |
| RAP1B | + |
| RRAS2 | + |
| SMAD1 | + |
| SMAD6 | + |
| SRC | + |
| TCF3 | + |
| AATF | + |
| ACVR1 | + |
| BCAR3 | + |
| CCNH | + |
| CCT2 | + |
| CDC2A | + |
| CHES1 | + |
| CRK | + |
| CRKL | + |
| CSPG6 | + |
| CTCF | + |
| CUL1 | + |
| CUL3 | + |
| DLG7 | + |
| DNAJA2 | + |
| DNM2 | + |
| FOXG1 | + |
| FRAP1 | + |
| GSPT1 | + |
| ID3 | + |
| JAK2 | + |
| MAP2K1 | + |
| MAP2K6 | + |
| MAPK1 | + |
| MYC | + |
| PBEF1 | + |
| PCNA | + |
| RAF1 | + |
| RALBP1 | + |
| RUVBL1 | + |
| SIAH1A | + |
| STRN3 | + |
| TNFSF5IP1 | + |
| TPX2 | + |
| TSG101 | + |
| TUBB3 | + |
| NOTCH1 | − |
| SMAD2 | − |
| SMAD4 | − |
| BCCIP | − |
| BRINP2 | − |
| COMMD5 | − |
| DAB2IP | − |
| DLGH1 | − |
| GAK | − |
| LZTS1 | − |
| MAPK6 | − |
| MSH2 | − |
| PTEN | − |
| RAD1 | − |
| RAP1A | − |
| RB1 | − |
| SMPD3 | − |
| TBRG1 | − |
| UBE1C | − |
The majority of these downregulated genes normally promote carcinogenesis as opposed to a small number that inhibit carcinogenesis.