Table 1.

List of genes that are downregulated by protective doses of MTM (300 nm) and SDK (75 nm), involved in carcinogenesis, and obtained from two networks identified in the microarray analysis: cell cycle and molecular mechanism of cancer

GeneMediate carcinogenesis
ADCY3+
ADCY8+
ADCY9+
BMPR1A+
HIF1A+
LRP5+
LRP6+
MAP2K4+
MAPK14+
NFKBIB+
PIK3C3+
PRKAG2+
RAP1B+
RRAS2+
SMAD1+
SMAD6+
SRC+
TCF3+
AATF+
ACVR1+
BCAR3+
CCNH+
CCT2+
CDC2A+
CHES1+
CRK+
CRKL+
CSPG6+
CTCF+
CUL1+
CUL3+
DLG7+
DNAJA2+
DNM2+
FOXG1+
FRAP1+
GSPT1+
ID3+
JAK2+
MAP2K1+
MAP2K6+
MAPK1+
MYC+
PBEF1+
PCNA+
RAF1+
RALBP1+
RUVBL1+
SIAH1A+
STRN3+
TNFSF5IP1+
TPX2+
TSG101+
TUBB3+
NOTCH1
SMAD2
SMAD4
BCCIP
BRINP2
COMMD5
DAB2IP
DLGH1
GAK
LZTS1
MAPK6
MSH2
PTEN
RAD1
RAP1A
RB1
SMPD3
TBRG1
UBE1C
  • The majority of these downregulated genes normally promote carcinogenesis as opposed to a small number that inhibit carcinogenesis.