Group characteristics
| Variable | APOE ϵ4− | APOE ϵ4+ | t | p |
|---|---|---|---|---|
| Demographic | ||||
| n | 62 | 33 | ||
| Age | 64.4 (7.0) | 62.6 (7.6) | 1.180 | 0.241 |
| Sex | 21 M/41 F | 13 M/20 F | 0.656 | |
| MMSE | 28.8 (0.91) | 29.1 (0.97) | −1.108 | 0.271 |
| Volumetrics | ||||
| L hippocampus (mm3) | 3300.4 (400.8) | 3370.4 (229.2) | −0.396 | 0.693 |
| R hippocampus (mm3) | 3275.4 (398.3) | 3401.5 (331.7) | −1.076 | 0.285 |
| Mean hippocampus (mm3) | 3287.9 (387.0) | 3386.0 (262.3) | −0.787 | 0.433 |
| ICV (mm3) | 1.333 × 106 (0.143 × 106) | 1.370 × 106 (0.128 × 106) | −1.233 | 0.221 |
| CVLT raw scores | ||||
| Learning | 56.0 (10.8) | 56.1 (11.9) | −0.018 | 0.985 |
| Learning—age adjusted | 0.357 | 0.734 | ||
| Recall | 12.8 (2.87) | 12.6 (2.78) | 0.060 | 0.952 |
| Recall—age adjusted | 0.583 | 0.561 | ||
| Recognition discriminability | 3.45 (0.64) | 3.17 (0.83) | 1.833 | 0.070 |
| Recognition discriminability—age adjusted | 2.269 | 0.026 |
Mean of MMSE and other variables are given with SD in parentheses. The volumes for left (L) hippocampus, right (R) hippocampus, and mean hippocampi are raw volumes not adjusted for intracranial volume (ICV). The respective t and p values are from the t test on the standardized residuals when using ICV as covariate in a regression fit. For sex, we used Fisher's exact test. Mean (SD) is reported separately for the three measures of verbal memory function derived from the CVLT. The respective t and p values are from two-tailed independent-samples t tests. The age-adjusted t and p values are from the t test on the standardized residuals from a regression fit with age as covariate. F, Female; M, male.