Condition | Mean ISI (ms) | τfast (ms) | %τfast | τslow (ms) |
---|---|---|---|---|
WT (8) | 83 ± 12 | 31 ± 8 | 63 ± 10 | 124 ± 28 |
cdh23tc317e (5) | 372 ± 59 | 49 ± 10 | 80 ± 4 | 458 ± 116 |
pcdh15t288 (4) | 619 ± 148 | 41 ± 20 | 85 ± 7 | 791 ± 197 |
2 mm DHS (7) | 391 ± 115 | 56 ± 19 | 83 ± 2 | 432 ± 105 |
1 mm ZD7288 (4) | 884 ± 280 | 65 ± 8 | 81 ± 5 | 429 ± 48 |
1 mm DK-AH 269 (4) | 189 ± 24 | 28 ± 5 | 82 ± 4 | 206 ± 34 |
2 mm DHS & 1 mm DK-AH 269 (4) | 7053 ± 4009 | n.a. | n.a. | n.a. |
1 mm BAPTA & 1 mm ZD7288 (3) | 4340 ± 490 | n.a. | n.a. | n.a. |
The condition column indicates the experimental condition with the number of individual larvae tested indicated in parentheses (n). The mean ISI time ± SEM was calculated from the total number of spikes in 400 s. The τfast, τslow, and %τfast values are mean ± SEM from the exponential equations fit to each cumulative ISI histogram generated. For all conditions except wild type, the two-phase exponential decay equation was the best fit (p < 0.0001). Note that the two wild-type recordings best fit with single-phase equations are not included in the wild-type condition (mean ISI = 67 and 57 ms; τ = 63 and 61 ms, respectively). Analyses were not applicable (n.a.) for conditions where not enough data were available.