Table 1.

Values for spontaneous spiking under different conditions

ConditionMean ISI (ms)τfast (ms)fastτslow (ms)
WT (8)83 ± 1231 ± 863 ± 10124 ± 28
cdh23tc317e (5)372 ± 5949 ± 1080 ± 4458 ± 116
pcdh15t288 (4)619 ± 14841 ± 2085 ± 7791 ± 197
2 mm DHS (7)391 ± 11556 ± 1983 ± 2432 ± 105
1 mm ZD7288 (4)884 ± 28065 ± 881 ± 5429 ± 48
1 mm DK-AH 269 (4)189 ± 2428 ± 582 ± 4206 ± 34
2 mm DHS & 1 mm DK-AH 269 (4)7053 ± 4009n.a.n.a.n.a.
1 mm BAPTA & 1 mm ZD7288 (3)4340 ± 490n.a.n.a.n.a.
  • The condition column indicates the experimental condition with the number of individual larvae tested indicated in parentheses (n). The mean ISI time ± SEM was calculated from the total number of spikes in 400 s. The τfast, τslow, and %τfast values are mean ± SEM from the exponential equations fit to each cumulative ISI histogram generated. For all conditions except wild type, the two-phase exponential decay equation was the best fit (p < 0.0001). Note that the two wild-type recordings best fit with single-phase equations are not included in the wild-type condition (mean ISI = 67 and 57 ms; τ = 63 and 61 ms, respectively). Analyses were not applicable (n.a.) for conditions where not enough data were available.