Table 2.

Effect of intra-BNST CGRP (800 ng bilaterally) on c-Fos expression in anxiety, fear, and startle-related neural regions

Brain areaVehicleBNST CGRPBNST αCGRP8-37Dorsal control CGRP
Infralimbic cortex157.9 ± 25.3178.9 ± 28.3102.3 ± 27.581.2 ± 26.6
Prelimbic cortex168.7 ± 48.8181.6 ± 24.8100.5 ± 26.194.2 ± 17.2
Ventrolateral septal nucleus128.1 ± 28.1494.3 ± 169.9†63.9 ± 22.7105.1 ± 24.9
Central nucleus of the amygdala87.7 ± 34.4356.0 ± 126.7*141.9 ± 36.2127.2 ± 26.7
Basolateral nucleus of the amygdala39.4 ± 4.136.9 ± 4.923.0 ± 4.7*25.6 ± 7.0
Medial nucleus of the amygdala88.1 ± 11.1159.6 ± 35.282.7 ± 10.264.0 ± 11.5
Paraventricular hypothalamic nucleus448.0 ± 95.61216.2 ± 237.1†401.9 ± 168.3465.5 ± 138.4
Lateral hypothalamus53.7 ± 6.387.6 ± 13.3*39.9 ± 11.447.9 ± 10.6
Locus ceruleus117.9 ± 48.9824.4 ± 145.4†9.2 ± 8.4†366.8 ± 122.1
Lateral parabrachial nucleus44.3 ± 11.3197.8 ± 22.9†33.5 ± 17.091.3 ± 49.1
Nucleus accumbens shell94.1 ± 35.2366.3 ± 34.5†64.3 ± 19.845.1 ± 12.1
Dorsal raphe nucleus33.7 ± 7.2143.2 ± 38.0†20.6 ± 6.662.6 ± 32.3
Ventrolateral periaqueductal gray52.9 ± 12.583.6 ± 21.532.9 ± 7.455.5 ± 14.9

  • Values are expressed as mean (±SEM) number of c-Fos-positive cells/mm2.

  • ↵*p < 0.05,

  • ↵†p < 0.01.