Table 5.

Brain regions showing an interaction effect between capsaicin and coughing

RegionPositive interactionRegionNegative interaction
Peak voxel coordinateZ scorePeak voxel coordinateZ score
xyzxyz
PMC−18−26623.12PFC265023.91
22−22623.21aMCC−224323.05
60−2383.22226323.39
M1−18−26583.54SMA00663.97
6−36583.48SFG426563.78
SM62−12303.47aINS421603.18
S2−44−32223.26IFG4228−43.26
48−26243.04
pINS−32−26143.58
38−32143.22
pMCC−8−12364.03
8−10384.15
PCC−8−32423.87
12−26383.56
  • The coordinates of maximally activated voxels are given in MNI space where x, y, and z coordinates represent the medial-lateral, anterior-posterior, and superior-inferior distances (in millimeters) from the anterior commissure. SMA, Supplementary motor area; PMC, premotor cortex; M1, primary motor cortex; SFG, superior frontal gyrus; PFC, prefrontal cortex; aMCC, anterior mid cingulate cortex; pMCC, posterior mid-cingulate cortex; SM, primary somatosensory/motor cortex; S2, secondary somatosensory cortex; aINS, anterior insula; pINS, posterior insula; PCC, posterior cingulate cortex; IFG, inferior frontal gyrus.

  • All activations identified at cluster-level significance of p < 0.05 (corrected).