Table 1.

FR rats exhibit normal inflammatory response to LPS

mRNA fold-change, LPS vs vehicle2-way ANOVA (interaction)
Ad libitumFRF(1,18)p
Genes
    Il1b16.68 ± 4.327.46 ± 6.10.0760.786
    Il67.23 ± 2.72.73 ± 0.72.1860.157
    Socs33.82 ± 1.12.97 ± 0.70.2490.624
    Nfkbia5.16 ± 0.63.01 ± 0.52.8830.107
Serum protein
    IL-65882 ± 1660 (pg/ml)3593 ± 1070 (pg/ml)1.6960.210
  • Hypothalamic mRNA levels of inflammatory cytokines in ad libitum fed versus FR rats following LPS treatment. Data are normalized to 18S RNA quantity and expressed as relative quantity compared to vehicle treatment. Serum IL-6 is expressed as serum protein concentration following LPS (vehicle-treated mean = 158.3 ± 80.6 pg/ml). Data are expressed as mean ± SEM.