Table 1.

Electrophysiological summary data for VTA DA neurons

GroupGroup sizesCM (pF)RM (MΩ)Ih (pA)Spontaneous activity
NnIncidenceRate (Hz)APD (ms)
Saline1322100 ± 3510 ± 44245 ± 3019 of 222.5 ± 0.33.4 ± 0.1
Cocaine
    3 mg/kg (1–2)2599 ± 10696 ± 144293 ± 694 of 52.5 ± 0.33.4 ± 0.2
    15 mg/kg (1–2)112495 ± 5875 ± 193208 ± 2321 of 242.9 ± 0.23.5 ± 0.2
    15 mg/kg (3–5)410100 ± 6419 ± 55277 ± 468 of 103.6 ± 0.43.2 ± 0.2
    15 mg/kg (10–12)38108 ± 6485 ± 82349 ± 387 of 82.8 ± 0.33.9 ± 0.4
    30 mg/kg (1–2)41094 ± 7413 ± 54301 ± 614 of 101.5 ± 0.43.2 ± 0.2
  • Summary electrophysiological properties of VTA DA neurons measured as part of the study depicted in Figure 1C. The time frame (in days after injection) during which electrophysiological recordings were made in VTA DA neurons from cocaine-treated mice is noted in parentheses next to the cocaine dose that was administered. Data were compiled from a total of N different mice per group and n total cells. Cocaine treatment had no significant impact on cell capacitance (CM: F(5,63) = 0.71, p = 0.62), input/membrane resistance (RM: F(5,71) = 1.85, p = 0.11), Ih current amplitude (Ih: F(5,69) = 1.66, p = 0.16), rate of spontaneous activity (rate: F(5,57) = 2.22, p = 0.07), or action potential duration (APD: F(5,57) = 0.83, p = 0.54).