Table 2.

Alignment of residues contributing to the aromatic box in the Cys-loop receptor family

ReceptorABCD
nAChY93W149Y190Y198W55
5-HT3E129W183F226Y234W90
MOD-1C120Y180Y221W226F83
GABACF138Y198Y241Y247Y102
GABAAY97Y157F200Y205F65
RDLF146F206L249Y254Y109
GlyF99F159Y202F207F63
  • Appropriate binding segments are labeled accordingly. Residues in bold have been shown to be involved in cation-π interactions.