Table 1.

Age-related differences in functional connectivity

Seed	Regional peak age differences	x	y	z	Z (Younger > Older)	Mean psc Younger	Mean psc Older
Right DLPFC	Right superior parietal cortex (BA 7)	34	−62	50	3.89	0.38 (0.31)	−0.12 (0.44)
	Right inferior parietal lobe (BA 40)⁺	60	−30	34	3.04	0.35 (0.32)	−0.47 (0.33)
	Left superior precuneus	10	−70	52	3.87	0.58 (0.38)	−0.02 (0.43)
	Left inferior parietal lobe (BA 7/40)	−42	−52	46	3.21	0.39 (0.28)	0.07 (0.25)
	MPFC	2	64	−10	−3.77	−0.51 (0.54)	0.33 (0.82)
	Left inferior frontal gyrus (BA 47)	−46	26	8	−3.75	−0.06 (0.33)	0.32 (0.40)
	Right occipitotemporal sulcus	36	−62	−10	3.25	−0.03 (0.27)	−0.26 (0.32)
	Midbrain⁺	8	−28	−10	3.09	0.13 (0.49)	−0.19 (0.32)
MPFC	PCC^*	−14	−56	14	3.42	0.17 (0.19)	−0.08 (0.19)
	Right intraparietal sulcus (BA 40)⁺	28	−46	48	−4.04	−0.26 (0.23)	−0.02 (0.18)
	Postcentral gyrus⁺	50	−22	38	−3.08	−0.20 (0.15)	−0.02 (0.15)
	Right inferior frontal gyrus	56	10	16	−3.42	−0.13 (0.15)	0.10 (0.16)
	Right prefrontal cortex (BA 46)	46	48	12	−3.29	−0.19 (0.42)	0.30 (0.57)
	Right anterior insula	34	22	10	−3.28	−0.08 (0.22)	0.21 (0.24)

x, y, and z refer to coordinates of the peak age differences in MNI space. Psc values show the mean (and SD) parameter estimates for each age group separately (converted to percentage signal change and based on a 6 mm³ ROI) in order to illustrate the origin of the age effect (Z).
↵*Significant at p < 0.001 (did not survive GRF cluster-size correction for multiple comparisons). ⁺ROIs for which we found significant associations with D1 receptor density (Fig. 2).