Table 1.

Ultracentrifugation of the Tg extract

Total Aβa [ng/μl] (relative amount to Tg extract)β-amyloid loadb [%] (relative amyloid load to Tg extract)
Tg extract14.838 ± 0.308 (1)4.62 ± 0.26 (1)
Supernatant0.005 ± 0.003 (0.004)1.35 ± 0.37 (0.29)
Pellet14.885 ± 1.181 (1)4.42 ± 0.80 (0.95)
  • aELISA measurements were done with three different Tg extracts. Mean ± SEM is indicated. Note that 2.5 μl of each fraction were injected.

  • bStereological quantification of induced β-amyloid. Mean ± SEM is indicated. Data are taken from Fig. 2E. Note that β-amyloid induction is not linear to the Aβ concentration in the extract (see Meyer-Luehmann et al., 2006). Thus, an additive effect of β-amyloid induction of the two fractions cannot be assumed.