Table 3.

Potency of LY2811376 cellular APP processing assays

AssayHEK293Swe1–40HEK293Swe1–42HEK293Swe CytotoxicityPDAPP 1o neuronal Aβ1–40PDAPP 1o neuronal Aβ1–42PDAPP 1o neuronal cytotoxicity
IC50 ± SD (nm)303 ± 112 (5)299 ± 58 (4)>100,000 (5)115 ± 42 (4)106 ± 46 (5)>50,000 (4)
  • Data are given as mean ± SD of four to five independent assays conducted as described in Materials and Methods. n values are in parentheses.