Table 1.

Basic demographics, clinical, MRI-based whole brain lesion volume and normalized thalamic volume information on healthy children, adult controls and the three patient groups

ControlsPatients
ChildAdultCISRRMSSPMS
N (F)126 (49)129 (69)9 (7)88 (68)12 (7)
(%Females)(39%)(54%)(78%)(77%)(58%)
Age (years)
    Mean ± SD12.2 ± 3.836.0 ± 11.339.2 ± 14.742.6 ± 9.854.7 ± 9.6
    Median11.334.040.244.756.1
    [Range][6.2–20.7][20.8–69.1][20.8–50.6][22.0–63.1][35.4–68.5]
EDSSNot applicable2.8 ± 3.211.1 ± 9.218.6 ± 9.6
1.310.118.9
[0.2–8.8][0.1–36.8][1.8–33.4]
Disease duration (years)Not applicable0.4 ± 0.81.7 ± 1.64.2 ± 1.3
01.54
[0–2][0–6.5][2–6]
Whole-brain lesion volume (ml)No lesions2.21 ± 2.7412.23 ± 11.6922.31 ± 9.70
1.347.2626.84
[0.15–8.16]0.18–44.79[6.98–37.27]
NTV1.09 ± 0.111.03 ± 0.101.00 ± 0.070.92 ± 0.110.82 ± 0.09
  • p age (CIS ∼ RRMS) = 0.32; p age (SPMS > RRMS) = 3 × 10−5; p age (CIS ∼ adult controls) = 0.41; p age (RRMS > adult controls) = 1.7 × 10−5; p NTV (adult controls > RRMS) = 4.8 × 10−13 (−11%); p NTV (CIS > RRMS) = 0.03; p NTV (CIS ∼ adult controls) = 0.36; p NTV (healthy children > adults) <1 × 10−4.