Table 2.

Correlation coefficient and statistical significance of the average normal-appearing thalamic qMRI metrics with age, disease duration, whole-brain LV, and EDSS in the 109 patients

qMRIAgeDD r (p)LV r (p)EDSS r (p)EDSS-covaried (age & LV) r (p)
VOLp−0.297−0.257−0.658−0.423−0.20
(0.002)(0.007)(1.07 × 10−14)(5 × 10−6)(0.04)
T20.3160.2850.450.3250.06
(0.001)(0.004)(2 × 10−6)(0.0008)(0.59)
FA0.0760.1120.0920.045−0.004
(0.45)(0.26)(0.36)(0.66)(0.97)
MD0.1720.1500.3560.1920.06
(0.08)(0.13)(0.0003)(0.05)(0.58)
AD0.2310.1960.4330.2250.046
(0.02)(0.048)(6 × 10−6)(0.02)(0.65)
RD0.1320.1170.2990.1650.06
(0.19)(0.24)(0.002)(0.10)(0.57)
  • The EDSS adjusted for age and LV provides a means to quantify the direct effects of disease progression without the confounding effects of natural aging and whole-brain LV. Statistically significant values (p < 0.05) are in bold. MD, AD, RD = mean, axial, and radial tensor diffusivities, respectively.