Table 1.

Activation and steady-state inactivation characteristics of Na_v1.8 currents in small-diameter sensory neurons

	V_1/2act (mV)	k_act	V_1/2inact (mV)	k_inact
Control	−8.45 ± 0.21	4.73 ± 0.19	−30.55 ± 0.17	4.72 ± 0.15
Control	(n = 13)		(n = 10)
CCL2 (10 nm)	−13.72 ± 0.22^*	3.5 ± 0.19	−37.02 ± 0.16^**	3.66 ± 0.14
CCL2 (10 nm)	(n = 4)		(n = 7)
CCL2 (100 nm)	−18.74 ± 0.31^***	4.47 ± 0.29	−40.61 ± 0.09^***	4.81 ± 0.08
CCL2 (100 nm)	(n = 11)		(n = 10)
CCL2 (100 nm) +INCB3344 (100 nm)	−7.47 ± 0.26^##	5.01 ± 0.23	−31.02 ± 0.16^###	3.59 ± 0.14
CCL2 (100 nm) +INCB3344 (100 nm)	(n = 7)		(n = 5)
CCL2 (100 nm) +PTX (250 ng/ml)	−7.04 ± 0.22^##	4.14 ± 0.20	ND	ND
CCL2 (100 nm) +PTX (250 ng/ml)	(n = 9)
CCL2 (100 nm) +gallein (20 μm)	−6.09 ± 0.22^###	4.10 ± 0.17	ND	ND
CCL2 (100 nm) +gallein (20 μm)	(n = 6)

V_1/2act and V_1/2inact are the membrane potentials for half-maximal channel activation or inactivation, respectively. k_act and k_inact represent the slope factors for activation and inactivation. The numbers in parentheses reflect numbers of recorded neurons. ND, Not determined.
↵**p < 0.01 and ***p < 0.001 indicate statistically significant differences with control group. ^##p < 0.01 and ^###p < 0.001 compared with CCL2 alone.