The effects of DHM on mIPSC kinetics and Itonic magnitudes in DGCs of naive rats
| Frequency (HZ) | mIPSC area (fC) | mIPSC amplitude (pA) | Rise time (ms) | Decay time (ms) | Itonic (pA) | |
|---|---|---|---|---|---|---|
| Baseline | 13.8 ± 0.7 | 585.2 ± 14.4 | 30.5 ± 2.1 | 2.0 ± 0.1 | 6.7 ± 0.6 | 22.5 ± 2.5 |
| DHM 0.1 μm | 14.0 ± 0.6 | 637.1 ± 19.8* | 30.9 ± 2.9 | 2.0 ± 0.2 | 7.5 ± 0.5 | 27.6 ± 1.4* |
| DHM 1 μm | 15.0 ± 0.6 | 715.7 ± 26.2* | 32.7 ± 2.6 | 2.1 ± 0.2 | 8.6 ± 0.5* | 44.0 ± 4.1* |
| DHM 10 μm | 15.9 ± 1.0 | 965.7 ± 30.9* | 36.1 ± 2.4 | 2.4 ± 0.3 | 9.6 ± 0.8* | 53.8 ± 2.9* |
| DHM 30 μm | 16.1 ± 1.7* | 956.7 ± 22.6* | 35.8 ± 3.0* | 2.4 ± 0.2 | 10.1 ± 0.8* | 54.0 ± 3.4* |
Data (mean ± SEM) were obtained from hippocampal slices. n = 5–7 neurons from 3 rats.
↵*p < 0.05 versus baseline (one-way ANOVA).