The effects of 1 mg/kg DHM on 4 g/kg EtOH-induced blood [EtOH] kinetics and LORR duration
| LORR duration (min) | Plasma [EtOH] at sampling time points (min) | ||||||
|---|---|---|---|---|---|---|---|
| 0a | 5 | 30 | 60 | 90 | 180 | ||
| E4 | 112.8 ± 8.0 | 143.3 ± 23.4 | 365.5 ± 7.7 | 379.5 ± 5.9 | 372.8 ± 5.4 | 361.6 ± 8.2 | 324.6 ± 21.4 |
| E4+D1 | 28.2 ± 4.0 | 156.4 ± 18.0 | 292.8 ± 30.1 | 322.2 ± 15.7 | 353.8 ± 0.9 | 347.7 ± 9.4 | 305.4 ± 28.5 |
| D100 | 2.9 ± 1.3 | ||||||
| D300 | 9.8 ± 4.3 | ||||||
| F20 | 0 | ||||||
| F200 | 0 | ||||||
High doses of DHM alone induced short-time LORR, while high dose flumazenil alone did not induced LORR. Data (mean ± SEM) were obtained from naive rats that received intraperitoneal injections of 4 g/kg EtOH (E4), coinjection of DHM (1 mg/kg) with EtOH (E4+D1), 100 mg/kg DHM (D100), 300 mg/kg DHM (D300), 20 mg/kg flumazenil (F20), or 200 mg/kg flumazenil (F200) alone (n = 8–10 rats/group).
↵aA value of 0 represents the time from intraperitoneal injection of EtOH or E+D to complete sample venous blood collection (0 to 3 min).