Table 1.

Measurements of synaptic vesicle accumulation

Ventral cordDorsal cord
Area ± SEM (n)aMaximum (μm2)Density ± SEM (n)bArea ± SEM (n)aMaximum (μm2)Density ± SEM (n)b
GABAergic
    Wild type0.80 ± 0.02 (530)3.925.7 ± 1.0 (16)0.83 ± 0.03 (344)3.022.9 ± 0.9 (10)
    fmi-1(ju43)1.10 ± 0.13 (102)*8.021.7 ± 0.9 (4)*1.27 ± 0.08 (157)*4.823.4 ± 0.7 (4)
    fmi-1(ju58)1.80 ± 0.14 (328)*17.417.6 ± 2.4 (9)*1.15 ± 0.06 (233)*7.021.7 ± 3.9 (6)
    fmi-1(tm306)1.43 ± 0.15 (199)*19.719.2 ± 1.9 (5)*0.89 ± 0.05 (147)3.418.4 ± 3.0 (4)*
    fmi-1(rh308)1.74 ± 0.20 (118)*18.916.3 ± 1.2 (4)*0.91 ± 0.05 (147)3.819.0 ± 1.5 (3)
    fmi-1(ju58)+[WRM066DB07]1.15 ± 0.10 (167)*9.019.9 ± 1.7 (7)*1.24 ± 0.10 (119)*7.717.5 ± 1.8 (4)*
    juIs1+[WRM0066DB07)0.86 ± 0.06 (203)6.026.5 ± 2.0 (6)0.92 ± 0.06 (184)6.023.1 ± 1.5 (5)
    fmi-1(tm306)+[Pacr-2::fmi-1]1.06 ± 0.07 (129)*4.615.5 ± 2.4 (4)*1.22 ± 0.09 (110)*3.817.2 ± 2.2 (4)
    fmi-1(tm306)+[Punc-25::fmi-1]2.11 ± 0.22 (135)*16.812.3 ± 2.4 (5)*1.14 ± 0.11 (77)*4.420.0 ± 4.4 (4)
    cdh-4(lq83)1.82 ± 0.11 (259)*14.716.6 ± 1.6 (7)*1.24 ± 0.09 (169)*7.220.3 ± 2.0 (4)*
    fmi-1(tm306);cdh-4(lq83)1.45 ± 0.13 (171)*13.216.6 ± 1.8 (5)*0.97 ± 0.07 (134)*6.018.1 ± 2.6 (4)*
    cdh-4(lq56)1.40 ± 0.10 (155)*6.716.7 ± 3.6 (5)*N/D
    fmi-1(tm306);cdh-4(lq56)1.48 ± 0.18 (113)*12.818.1 ± 1.0 (3)*N/D
    eri-1(mg366)juIs1;CDH-4(RNAi)1.56 ± 0.15 (137)*11.316.7 ± 1.8 (4)*N/D
    fmi-1(tm306); eri-1(mg366)juIs1;CDH-4(RNAi)1.57 ± 0.24 (101)*18.917.8 ± 3.1 (4)*N/D
Cholinergic
    Wild type0.90 ± 0.06 (281)6.226.7 ± 2.0 (5)1.03 ± 0.07 (208)6.026.1 ± 2.8 (4)
    fmi-1(ju58)0.98 ± 0.06 (459)10.923.8 ± 2.1 (9)1.17 ± 0.09 (323)*16.626.9 ± 2.5 (7)
  • N/D, Not determined.

  • aMeasurements are in square micrometers.

  • bAverage number of puncta observed per 100 μm.

  • *p < 0.01, significantly different from wild type;

  • p < 0.01, significantly different than fmi-1;

  • not significantly different from fmi-1(tm306).