Table 4.

The regional changes associated with the return of consciousness and the loss of consciousness observed in the combined analysis of dexmedetomidine and propofol revealed by PLS

Brain regionsBrodmann areaMNI coordinates (in mm) x,y,zCluster size (voxels)BSRp value
Latent variable 2
    Positive salience—shown in Figure 5
        Anterior cingulate/caudate/thalamus10/2412, 24, 161034110.5547<0.0001
        R cerebellum16, −52, −5826946.0852<0.0001
        L cerebellum−12, −64, −466695.0053<0.0001
        Pons2, −12, −401674.6936<0.0001
        Thalamus10/2426, −32, 61234.0715<0.0001
    Negative salience
        R parahippocampal gyrus20/35/3624, −8, −285591−16.6896<0.0001
        L parahippocampal gyrus20/35/36−28, −34, −186551−11.0476<0.0001
        R postcentral gyrus2/3/458, −20, 244541−6.4574<0.0001
        R inferior parietal39/4042, −46, 48270−5.7562<0.0001
        R cuneus17/186, −106, −4462−5.7045<0.0001
        L precentral gyrus4/6/9−38, 2, 36,202−4.6472<0.0001
        L middle temporal gyrus21/37/39−58, −62, −6324−4.6033<0.0001
        L cerebellum/culmen−4, 44, −28123−4.1926<0.0001
Latent variable 1
    Positive salience—shown in Figure 6
        R inferior parietal/precuneus39/40/752, −54, 48974412.8661<0.0001
        L inferior parietal/angular gyrus39−48, −72, 36456012.5331<0.0001
        R middle temporal gyrus21/37/3976, −28, −169209.552<0.0001
        R cerebellum32, −78, −5033539.4273<0.0001
        L orbital gyrus10/47−14, 36, −28198598.3257<0.0001
        L cerebellum−36, −78, −4643296.8598<0.0001
        Thalamus/medial dorsal nucleus10/248, −14, 026426.8006<0.0001
        R superior frontal gyrus8/9/10/1114, 36, 546875.9129<0.0001
Brainstem4, −24, −501035.9054<0.0001
    Negative salience
        R superior temporal gyrus3840, −46, 1454536−19.4447<0.0001
  • Corresponding clusters are shown in Figures 5 and 6.