Intrinsic membrane properties by cell type
| P, n = 49 | WT FS, n = 52 | G42, n = 26 | WT non-FS, n = 57 | GIN, n = 46 | p (GIN versus WT non-FS) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| Age, d | 22.6 | 3.5 | 22.7 | 2.7 | 22.1 | 2.5 | 21.3 | 3.2 | 24.8 | 3.8 | <0.001 |
| Max. firing rate, Hz | 44.7 | 18.9 | 201.7 | 44.7 | 229.1 | 50.7 | 89.3 | 48.4 | 96.9 | 51.8 | |
| Resting Vm, mV | −66.5 | 5.6 | −68.0 | 6.4 | −67.8 | 6.1 | −65.6 | 6.7 | −61.9 | 6.8 | 0.01 |
| Rin, MΩ | 126.4 | 82.7 | 119.5 | 36.6 | 119.4 | 38.9 | 195.0 | 88.8 | 279.6 | 85.8 | <0.001 |
| taum, ms | 18.4 | 4.2 | 8.6 | 3.3 | 8.1 | 1.9 | 15.7 | 6.7 | 16.5 | 5.2 | |
| ISI(last) / ISI(first) | 3.64 | 1.48 | 1.27 | 0.39 | 1.29 | 0.35 | 3.24 | 1.65 | 4.83 | 2.90 | 0.01 |
| AP width, ms | 1.20 | 0.20 | 0.48 | 0.10 | 0.48 | 0.10 | 0.98 | 0.32 | 0.91 | 0.38 | |
| AHP time, ms | 31.6 | 9.5 | 3.5 | 1.6 | 4.5 | 3.2 | 12.4 | 9.7 | 32.7 | 17.5 | <0.001 |
| AHP amplitude, mV | −17.1 | 3.6 | −16.5 | 3.4 | −15.1 | 5.3 | −13.5 | 3.9 | −11.4 | 2.7 | 0.003 |
| Vthresh, mV | −41.5 | 3.5 | −40.0 | 6.0 | −38.2 | 6.1 | −38.1 | 7.6 | −40.6 | 5.9 | 0.04 |
| Rheobase I, nA | 0.09 | 0.04 | 0.20 | 0.08 | 0.20 | 0.10 | 0.13 | 0.00 | 0.06 | 0.05 | 0.01 |
Values are derived from responses to hyperpolarizing and depolarizing current steps (compare Fig. 1B). Max., maximum; Rin, input resistance; taum, membrane time constant; ISI(last)/ISI(first), degree of spike rate adaptation; Vthresh, spike threshold. Other terms as defined in main text.