Cortical firing rates in response to sinusoidally modulated, simulated M/T population currents: peak cortical firing rate
| Simulated respiratory rhythm | ||||||
|---|---|---|---|---|---|---|
| 2 Hz rhythm | 8 Hz rhythm | |||||
| Plasticity | ||||||
| F | FD | D | F | FD | D | |
| M/T FR (Hz) | ||||||
| 12 | 12.9 ± 1.4 | 9.3 ± 1.4 | 6.9 ± 1.0 | 16.4 ± 2.0* | 9.8 ± 1.4 | 8.3 ± 1.1 |
| 16 | 17.9 ± 1.7†† | 12.0 ± 1.2†† | 11.4 ± 1.4†† | 24.1 ± 2.1**†† | 14.2 ± 1.6†† | 12.0 ± 1.7†† |
| 20 | 20.0 ± 1.8 | 13.4 ± 1.6 | 12.2 ± 1.2 | 31.3 ± 2.7**†† | 22.8 ± 2.9**†† | 15.3 ± 1.3**†† |
| 24 | 21.8 ± 2.7†† | 15.3 ± 1.7†† | 13.2 ± 1.4†† | 34.4 ± 2.8**†† | 27.6 ± 2.9**†† | 21.3 ± 2.6**†† |
| Range (Hz) | 11.2 ± 1.8†† | 6.3 ± 0.6 | 5.3 ± 0.5 | 21.0 ± 2.2**†† | 18.3 ± 1.7** | 11.8 ± 1.8** |
Peak, phase-locked cortical firing rates (Hz) in response to simulated M/T currents for the same conditions as in Table 2.
↵For each synapse type, the peak firing rates and range of firing rates were higher during 8 Hz rhythms than 2 Hz (*p < 0.05; **p < 0.01, paired t test). In addition, comparisons between cortical responses to discrete changes in presynaptic rates (i.e., 12 vs 16, 16 vs 20, 20 vs 24) yielded significant changes in both the 2 and 8 Hz cases (††p < 0.01, paired t test). Finally, the range of mean cortical firing rates that represent the 12–24 Hz change in presynaptic rate was significantly greater in the F synapse case (††p < 0.01, unpaired t test) than the FD or D synapses.