Table 2.

Parameters for intrinsic membrane kinetics of the default model DTN

Parameters
DTN model parameters
    Soma diameter13 μm
    Cm1.0 μF/cm2
    Temperature36°C
    χ̇αχ(1 − χ) − βχ(χ)
Sodium (Na) channels
    INaḡNam3h(V−ENa)
    αm(−0.32(V + 29))/(exp(−(V + 29)/4) − 1)
    βm(0.28(V + 2))/(exp((V + 2)/5) − 1)
    αh0.128 exp(−(V + 25)/18)
    βh4/(exp((−(V + 2))/5) + 1)
    ḡNa100 mS/cm2
    ENa50 mV
Potassium (K) channels
    IKḡKn4(V−EK)
    αn(−0.032(V + 27))/(exp(−(V + 27)/5) − 1)
    βn0.5 exp(−(V + 32)/40)
    ḡK8 mS/cm2
    EK−90 mV
Passive leak channels
    Ileakḡleak(V−Eleak)
    ḡleak0.25 mS/cm2
    Eleak−65 mV

  • Cm, Membrane capacitance; m, h, n, channel gating variables; αχ, βχ, gating variable dynamics functions where χ stands in for m, h, or n; V, membrane potential; INa,K,leak, current; ḡNa,K,leak, maximum channel conductance; ENa,K,leak, channel reversal potential; χ̇, gating variable differential equation. Sodium, potassium, and leak currents are based on kinetics described by Traub and Miles (1991) and implemented by Destexhe et al. (1996).