Table 1.

Postsynaptic glutamatergic and GABAergic receptor current parameters of the default model DTN

Parameters
AMPA receptors
    IAMPAḡAMPAr(V − EAMPA)
    ḡAMPA4 nS
    Embedded Imageα[T](1 − r) − βr
    [T]1.0 mm for 1 ms
    EAMPA0 mV
    α1.1/ms mm
    β0.19/ms
NMDA receptors
    INMDAḡNMDAB(V)r(V − ENMDA)
    ḡNMDA20 nS
    Mg2+ block; B(V)(1 + exp(−0.062V)[Mg2+]o/3.57)−1
    [Mg2+]o1.0 mm
    Embedded Imageα[T](1 − r) − βr
    [T]1.0 mm for 1 ms
    ENMDA0 mV
    α0.072/ms mm
    β0.0066/ms
GABAA receptors
    IGABAAḡGABAAr(V − EGABAA)
    ḡGABAA2.5 nS
    Embedded Imageα[T](1 − r) − βr
    [T]1.0 mm for 1 ms
    EGABAA−80 mV
    α5.0/ms mm
    β0.18/ms

  • The AMPA and NMDA receptors were modeled with a single synapse per input, whereas the GABAA receptors had 10 synapses per input. r, Proportion of open channels; dt, simulation time step; [T], neurotransmitter concentration; [Mg2+]o, Mg2+ concentration outside of the cell; EAMPA,NMDA,GABAA receptor reversal potential; α, receptor activation rate constant; β, receptor deactivation rate constant. Conductance (ḡ) values are written as the total conductance combined over all inputs of that type. Equation and parameter values for each receptor are from the study by Destexhe et al. (1998). The Mg2+ block function, B(V), was first derived by Jahr and Stevens (1990).