NF | LF | FD | ||||
---|---|---|---|---|---|---|
Saline | l-dopa | Saline | l-dopa | Saline | l-dopa | |
Folate (nmol/L) | 138 ± 28 | 130 ± 18 | 20.3 ± 2.9* | 24.9 ± 4.6* | 5.2 ± 1.1* | 4.8 ± 0.7* |
tHcy (μmol/L) | 8.8 ± 1.7 | 47.8 ± 17.7^ | 13.5 ± 2.4* | 63.8 ± 16.3*^ | 86.5 ± 15.0* | 131.5 ± 12.4*^ |
LF and FD diets are effective in lowering folate concentrations in blood, which for each diet were similar between saline and l-dopa-treated mice. l-Dopa treatment induced a marked increase in plasma tHcy levels, an effect that was exacerbated by LF and FD diets. Values represent mean ± SD for six mice in each group.
↵*Compared to NF diet in the same treatment group (ANOVA with Dunnett's multiple-comparison t test; p < 0.05).
↵^Compared to saline treated in the same diet group (t test; p < 0.05).