Table 1.

Expression of several groups of genes directly related to the BBB function

Probe set identificationGene symbolGene nameNeonatalAdult
ContraIpsiIpsi/contraContraIpsiIpsi/contra
Pan endothelial genes
    1393067_atTekEndothelial-specific receptor tyrosine kinase (Tie2)11,64711,9851.012,77614,5251.1
Tight junctions
    1374104_atCldn5Claudin 524,73023,4340.920,18117,9640.9
    1368115_atCldn3Claudin 3951001.01531280.8
    1373182_atCldn12Claudin 124183080.75314850.9
    1378753_atOclnOccludin960071320.7804730340.4a
    1372473_atTjp1Tight junction protein 1 (ZO-1)13,47312,3290.912,88710,9710.9
    1370940_atTjp2Tight junction protein 1 (ZO-2)323735031.1266441121.5
    1384143_atCgnCingulin334620.2a1351170.9
    1389107_atCgnl1Cingulin-like 111,85788560.7962593451.0
Adhesion molecules
    1391946_atSelpP-selectin39109428.1a434009.4
    1388018_atSeleE-selectin22125557.6b214414214.3b
    1387202_atIcam1Intracellular adhesion molecule 1147156373.864618922.9
    1368474_atVcam1Vascular cell adhesion molecule 159320583.57478071.1
    1370043_atAlcamActivated leukocyte adhesion molecule9624890.58906200.7
Extracellular matrix components
    1370927_atCol12a1Collagen, type XII, α 1604237.0a651121.7
    1388939_atCol15a1Collagen, type XV, α 11147076.2a901191.3
    1388459_atCol18a1Collagen, type XVII, α 1171255733.33649252.5
    1387854_atCol1a2Collagen, type I, α 22732951.11562351.5
    1377631_atCol9a3Collagen, type IX, α 3849333150.47071810.3
    1370895_atCol5a2Collagen, type V, α 2721569241.0157214981.0
    1374705_atCol4a5Collagen, type IV, α 5918374350.8566435230.6
    1388494_atCol4a2Collagen, type IV, α 215,64316,9101.1147869664.7a
    1372439_atCol4a1Collagen, type IV, α 115,62219,5991.3327813,5714.1a
    1370959_atCol3a1Collagen, type III, α 19485270.6702553.6a
    1368380_atVtnVitronectin13242460.227013960.1
    1370234_atFn1Fibronectin 119,20619,7781.014,52997280.7
    1390404_atLama2Laminin, α 214232920.210664950.5
    1392926_atLama1Laminin, α 112156110.5142840.6
    1388932_atLama5Laminin, α 5107914131.365616182.5a
    1398275_atMmp9Matrix metallopeptidase 9187880.542263163.2a
    1370301_atMmp2Matrix metallopeptidase 21311651.32291010.4
Angiogenesis regulators
    1368463_atVegfcVascular endothelial growth factor C222127811.3112010040.9
    1380854_atVegfbVascular endothelial growth factor B3242490.83452020.6
    1373807_atVegfaVascular endothelial growth factor A64520.81561641.1
    1367948_a_atKdrVEGFR-214,62612,9740.9415110,9162.6a
    1369216_a_atFlt4VEGFR-395570.637401.1
    1370492_a_atFlt1VEGFR-1365523480.6119424172.0
    1374207_atAngpt2Angiopoietin 2956960660.6276114,5865.3a
    1381487_atAngpt1Angiopoietin 114141.016130.8
    1398358_a_atItgb5Integrin β 52502110.84422040.5
    1368819_atItgb1Integrin β 110,56611,5301.1865411,7361.4
    1370937_a_atItga7Integrin α 73231990.63771630.4
    1385649_atItga5Integrin α 52402321.048601.2
    1387144_atItga1Integrin α 1272318800.77676370.8
Transporters
    1388750_atTfrcTransferrin receptor20,17166090.3735436600.5
    1370848_atSlc2a1Glut-115,27316,0061.021,09719,6090.9
    1386981_atSlc16a1MCT118,73094080.5473541560.9
    1387280_a_atSlc7a5TA139507350.26783130.5
    1368391_atSlc7a1CAT117,43986030.511,27555450.5
    1370367_atSlc1a1EEAC194550.6147521131.4
    1368461_atSlc22a8OAT3715711530.212761660.1
    1387970_atSlc38a5JM24958485160.93966481.6
    1370824_atSlc38a3Snat3670630920.516226930.4
    1368295_atSlco2b1OATP-B241813200.5183110170.6
    1370205_atSlco1c1OATP-F24,64812,1470.510,0528230.1
    1387093_atSlco1a4Oatp2427218590.423,98974970.3
    1380577_atAbcg2Bcrp10,46657740.613,27925490.2
    1370583_s_atAbcb1a, Abcb1bP-glycoprotein247210780.413626040.4
    1370465_atAbcb1aP-glycoprotein426919650.5497419410.4
Wnt mediators
    1387184_atAxin2Axin 2312690.270420.6
    1383785_atLef1Lymphoid enhancer binding factor 1328336891.1307123380.8
    1388994_atFzd6Frizzled 6580269121.2148818361.2
    1373067_atCtnnb1b-catenin440952931.2814664660.8
  • aStatistical significance: only this age.

  • bStatistical significance: both ages.