Table 1.

Effects of α7nAChR agents on FLNA recruitment to α7nAChR

AgentFLNA/α7nAChR ratio (stimulation vs vehicle, %)Statistics vs vehicle, pAβ42 effect, %Statistics vs Aβ42, p
Vehicle0.07 ± 0.01
0.1 μm Aβ420.73 ± 0.05 (1012.3 ± 104.9)<0.0001100
1 μm Aβ400.28 ± 0.03 (341.9 ± 65.1)0.00134.8 ± 6.6<0.001
1 μm Nicotine0.13 ± 0.02 (107.7 ± 31.4)<0.00111.0 ± 3.20.001
1 μm PNU2829870.12 ± 0.02 (87.1 ± 37.9)0.018.9 ± 3.90.001
1 μm α-Bungarotoxin0.07 ± 0.01 (7.5 ± 6.6)0.650.8 ± 0.7<0.001
1 μm Methyllycaconitine0.08 ± 0.02 (19.8 ± 12.2)0.212.0 ± 1.2<0.001
1 μm Galantamine0.08 ± 0.02 (17.1 ± 14.6)0.371.7 ± 1.5<0.001
1 μm Memantine0.21 ± 0.03 (225.9 ± 38.5)<0.0000123.0 ± 3.90.001