AP amplitude (mV) | HW (ms) | dV/dt (V/s) | −dV/dt (V/s) | IMP (mV) | τdecay (ms) | |
---|---|---|---|---|---|---|
WT | 69.9 ± 2.2 | 0.22 ± 0.01 | 397 ± 20 | 343 ± 14 | −48.0 ± 0.7 | 11.1 ± 0.4 |
S218L | 66.3 ± 1.6 | 0.22 ± 0.01 | 400 ± 22 | 369 ± 14 | −50.4 ± 0.8 | 10.3 ± 0.4 |
t test | 0.22 | 0.96 | 0.93 | 0.21 | 0.03 | 0.64 |
Absolute amplitude of action potential (AP); half-width (HW) (ms) of AP; maximum rising slope (dV/dt) (V/s); maximum repolarizing slope (−dV/dt) (V/s); interspike membrane potential (IMP), and decay time constant (τdecay) of the membrane capacitance calculated from 19 WT and 18 Cacna1aS218L Purkinje cells.