Table 1.

Action potential kinetics and passive Purkinje cell properties

AP amplitude (mV)HW (ms)dV/dt (V/s)dV/dt (V/s)IMP (mV)τdecay (ms)
WT69.9 ± 2.20.22 ± 0.01397 ± 20343 ± 14−48.0 ± 0.711.1 ± 0.4
S218L66.3 ± 1.60.22 ± 0.01400 ± 22369 ± 14−50.4 ± 0.810.3 ± 0.4
t test0.220.960.930.210.030.64
  • Absolute amplitude of action potential (AP); half-width (HW) (ms) of AP; maximum rising slope (dV/dt) (V/s); maximum repolarizing slope (−dV/dt) (V/s); interspike membrane potential (IMP), and decay time constant (τdecay) of the membrane capacitance calculated from 19 WT and 18 Cacna1aS218L Purkinje cells.