Autoradiographical binding of 125I[Tyr14]N/OFQ to the NOP receptor in cortical and subcortical areas of sham-operated, untreated 6-OHDA lesioned (hemiparkinsonian), and dyskinetic rats
| Sham operated | Hemiparkinsonian | Dyskinetic | |
|---|---|---|---|
| Level AP −0.30 to −0.92 mm | |||
| M1 | |||
| Ipsi | 71.6 ± 6.7 | 89.8 ± 14.9 | 94.6 ± 6.1 |
| C/L | 77.2 ± 7.6 | 83.8 ± 14.1 | 90.6 ± 6.2 |
| M2 | |||
| Ipsi | 80.8 ± 8.6 | 90.9 ± 14.9 | 100.3 ± 6.8 |
| C/L | 81.1 ± 6.1 | 90.0 ± 13.7 | 97.5 ± 6.9 |
| CPuDL | |||
| Ipsi | 22.7 ± 4.8 | 30.6 ± 6.2 | 31.5 ± 3.5 |
| C/L | 23.0 ± 4.9 | 20.9 ± 4.5 | 21.5 ± 3.0 |
| CPuVL | |||
| Ipsi | 24.8 ± 4.7 | 30.1 ± 3.9 | 34.3 ± 3.1 |
| C/L | 25.9 ± 4.7 | 22.5 ± 3.8 | 25.9 ± 2.8 |
| CPuDM | |||
| Ipsi | 24.8 ± 4.9 | 28.6 ± 3.0 | 30.4 ± 3.4 |
| C/L | 26.1 ± 4.7 | 19.2 ± 1.5 | 21.6 ± 3.1 |
| CPuCe | |||
| Ipsi | 27.0 ± 6.4 | 27.7 ± 4.2 | 30.6 ± 3.7 |
| C/L | 27.7 ± 6.5 | 20.7 ± 3.4 | 23.1 ± 3.6 |
| CPuVM | |||
| Ipsi | 29.7 ± 3.0 | 39.5 ± 6.3 | 36.9 ± 3.1 |
| C/L | 29.5 ± 3.1 | 30.0 ± 5.3 | 27.1 ± 3.0 |
| Level AP −3.60 to −5.80 mm | |||
| M1 | |||
| Ipsi | 72.4 ± 6.8 | 89.7 ± 13.9 | 96.6 ± 7.2 |
| C/L | 75.4 ± 8.6 | 84.8 ± 12.1 | 94.6 ± 7.3 |
| M2 | |||
| Ipsi | 78.4 ± 5.0 | 85.7 ± 14.0 | 90.1 ± 7.5 |
| C/L | 76.4 ± 8.6 | 84.8 ± 13.0 | 91.0 ± 7.8 |
| STN | |||
| Ipsi | 17.4 ± 1.7 | 32.3 ± 6.1 | 35.4 ± 7.0 |
| C/L | 18.5 ± 4.1 | 30.9 ± 6.0 | 38.5 ± 7.4 |
| SNr | |||
| Ipsi | 25.5 ± 1.3 | 16.0 ± 4.6 | 16.6 ± 4.4 |
| C/L | 25.1 ± 2.7 | 28.1 ± 4.9 | 26.8 ± 4.7 |
| SNc | |||
| Ipsi | 22.9 ± 0.6 | 17.7 ± 3.9 | 19.9 ± 3.4 |
| C/L | 24.6 ± 1.8 | 34.7 ± 3.2 | 32.1 ± 4.8 |
Twenty micrometer coronal sections were cut at two different brain levels from bregma: AP −0.30 to −0.92 and −3.60 to −5.80. Absolute binding values are given as fmol/mg tissue. Ce, Cerebellar; CPu, caudate-putamen; DL, dorsolateral; DM, dorsomedial; VL, ventrolateral; VM, ventromedial.