Table 1.

Drug effects on gamma frequency

SalineNembutal (5 mg/kg)MK-801 (0.05 mg/kg)
56.551.957.3
p = 6 × 10−5p = 0.12
Rat 924556.1 Hz50.5 Hz57.0 Hz
p = 3 × 10−8p = 0.2
Rat 924456.7 Hz52.5 Hz58.0 Hz
p = 0.002
Rat 923356.8 Hz52.7 Hz57.0 Hz
p = 3 × 10−4p = 0.9
  • Values are peak gamma frequencies, calculated by averaging across trials and 500 ms trial phases for each session and then averaging across sessions. p values are the results of t test comparisons of peak gamma frequency between drug and saline conditions. Top row shows means and p values across rats, and the bottom rows show means and p values within rats, across session. As a result of poor behavior in rat 9244, data collection under treatment with MK-801 was successfully obtained in only one session, so a within-rat comparison could not be made. Gamma frequency was consistently slower after administration of the barbiturate Nembutal (sodium pentobarbital), but gamma frequency after the NMDA antagonist MK-801 was not different from the saline condition.