Wild type | wtTARDBP | mutTARDBP | |
---|---|---|---|
Fast-twitch muscle | |||
Vm (mV) | −68.2 ± 2.3 (15) | −67.1 ± 4.8 (10) | −66.3 ± 2.1 (15) |
Cm (pF) | 38.6 ± 5.2 (15) | 38.7 ± 3.1 (10) | 37.6 ± 4.3 (15) |
Rm (MΩ) | 152.7 ± 23.3 (15) | 156.7 ± 27.1 (10) | 164.1 ± 45.1 (15) |
Tetanus frequency (Hz) | 41.0 ± 1.3 (10) | 40.8 ± 1.3 (10) | 40.4 ± 1.2 (10) |
CaP (primary motoneuron) | |||
Vm (mV) | −64.1 ± 1.2 (16) | −62.0 ± 1.4 (10) | −64.4 ± 0.9 (15) |
Cm (pF) | 6.8 ± 0.6 (16) | 6.5 ± 0.8 (10) | 5.6 ± 0.9 (15) |
Rm (MΩ) | 263.8 ± 33.9 (16) | 263.5 ± 26.6 (10) | 242.6 ± 20.8 (15) |
Rheobase (pA) | 86.6 ± 5.1 (10) | 86.2 ± 8.7 (10) | 65.3 ± 6.1 (15)* |
AP frequency (Hz) @ 20 pA injection | 0 (17) | 0 (7) | 0 (20) |
AP frequency (Hz) @ 40 pA injection | 0 (17) | 0 (7) | 10.6 ± 7.6 (20)* |
AP frequency (Hz) @ 60 pA injection | 0 (17) | 0 (7) | 38.3 ± 13.4 (20)* |
AP frequency (Hz) @ 80 pA injection | 26.3 ± 10.2 (17) | 25.7 ± 16.7 (7) | 60.3 ± 14.9 (20)* |
Threshold (mV) | −32.5 ± 1.4 (10) | −31.5 ± 1.8 (10) | −35.4 ± 1.3 (15) |
AP, action potential. Asterisks represent statistical significant differences from wild-type zebrafish.