Regional changes in mice exposed to cocaine during adolescence
| Brain region | Direction | Hemisphere |
|---|---|---|
| Orbital frontal cortex | Increase | Right |
| Striatum (anterior) | Increase | Right |
| Striatum (posterior) | Decease | Bilateral |
| Nucleus accumbens | Decease | Bilateral |
| Anterior cingulate cortex | Decrease | Bilateral |
| Ventral pallidum | Decrease | Bilateral |
| Medial forebrain bundle | Decrease | Bilateral |
| Insular cortex | Decrease | Bilateral |
| Cortical amygdaloid area | Decrease | Bilateral |
| Substantia nigra | Increase | Bilateral |
| Anterior olfactory area | Increase | Right |
| Corpus callosum | Increase | Bilateral |
| Rhinal cortex | Decrease | Bilateral |
| Piriform cortex | Decrease | Right |
| Medulla | Increase | Bilateral |
Brain regions where volumetric differences were observed following cocaine exposure during adolescence. Direction of change refers to cocaine exposed mice relative to saline exposed mice. Changes were observed at the voxel level after correcting for multiple comparisons with 5% FDR correction. See Figure 1 for visualization of these data.