Expression of markers of glial cells and proliferation in the 22L and the ME7 models of prion disease
| NBH | ME7 | 22L | ||||
|---|---|---|---|---|---|---|
| CA1 | TH | CA1 | TH | CA1 | TH | |
| Iba1 | 63.31 ± 12.43 | 64.57 ± 9.39 | 240.66 ± 22.13*** | 328.15 ± 34.94*** | 228.30 ± 22.63** | 282.71 ± 14.31** |
| GFAP | 387.94 ± 21.03 | 19.21 ± 4.64 | 409.45 ± 22.44 | 448.31 ± 26.58*** | 362.81 ± 55.37 | 529.76 ± 26.50*** |
| PCNA | 13.04 ± 1.06 | 18.30 ± 5.61 | 83.54 ± 13.66* | 126.96 ± 29.07* | 41.21 ± 3.26* | 164.94 ± 36.44** |
| pHH3 | 3.08 ± 0.51 | 1.70 ± 0.40 | 16.23 ± 2.36** | 17.74 ± 3.66* | 14.70 ± 3.12* | 13.93 ± 1.57* |
Immunohistochemical analysis of the expression of Iba1 (microglia), GFAP (astrocytes), PCNA (proliferation), and pHH3 (proliferation) in the CA1 region of the hippocampus and the thalamus of prion disease (ME7, 22L) and control (NBH) mice. Quantification data expressed as mean ± SEM of the number of positive cells per square millimeter.
↵*p < 0.05,
↵**p < 0.01,
↵***p < 0.001. Data were analyzed with a two-way ANOVA and a post hoc Tukey test.