Table 1.

Effects of IbTX, apamin, and CPA on electrophysiological properties of SPNs

IbTX (n = 6)Apamin (n = 6)CPA (n = 8)CPA in apamin (n = 4)
ControlIbTXControlApaminControlCPAApaminCPA
AP threshold (mV)−46.6 ± 1.5−46.8 ± 1.7−47.6 ± 1.4−48.2 ± 1.5−47.3 ± 1.6−47.7 ± 1.6−48.2 ± 1.2−49.5 ± 1.1
AP half-width (ms)0.80 ± 0.021.05 ± 0.05**0.72 ± 0.020.73 ± 0.020.75 ± 0.020.76 ± 0.020.74 ± 0.020.75 ± 0.02
AP decay rate (ms)0.38 ± 0.020.59 ± 0.03**0.33 ± 0.010.33 ± 0.010.35 ± 0.010.36 ± 0.010.34 ± 0.010.34 ± 0.00
Latency to first AP (ms)567 ± 34510 ± 23560 ± 25410 ± 21**551 ± 37401 ± 51**437 ± 17458 ± 22
Interspike interval (ms)175 ± 6174 ± 10171 ± 8101 ± 2***159 ± 7116 ± 11**104 ± 1108 ± 5
fAHP amplitude (mV)9.7 ± 0.64.0 ± 0.8***10.2 ± 1.19.8 ± 1.111.5 ± 0.410.9 ± 0.411.1 ± 1.011.1 ± 1.1
sAHP amplitude (mV)14.5 ± 0.514.2 ± 0.414.5 ± 0.411.3 ± 0.6***14.4 ± 0.512.9 ± 0.4**12.0 ± 0.311.9 ± 0.4
RMP (mV)−87.1 ± 1.6−87.6 ± 1.3−89.8 ± 1.1−90.7 ± 1.3−89.4 ± 1.7−90.1 ± 2.0−91.3 ± 0.9−91.8 ± 1.0
Input resistance (MΩ)61.0 ± 9.665.6 ± 11.153.2 ± 5.254.5 ± 5.456.1 ± 5.756.8 ± 5.553.3 ± 8.453.6 ± 8.5
  • *p < 0.05;

  • **p < 0.01;

  • ***p < 0.001 (paired t test).