Representative biological processes of gene ontology that are enriched among the altered gene expression by Apc gene disruption analyzed by DAVID program
| Terms of biological processes | Gene count | p value | Fold enriched |
|---|---|---|---|
| Oligodendrocyte differentiation | 4 | 0.0036 | 12.7 |
| Negative regulation of microtubule polymerization or depolymerization | 3 | 0.0254 | 11.9 |
| Myelination | 5 | 0.0026 | 8.6 |
| Axon ensheathment | 5 | 0.0031 | 7.1 |
| Negative regulation of cytoskeleton organization | 5 | 0.0067 | 6.6 |
| Regulation of Wnt receptor signaling pathway | 4 | 0.0229 | 6.5 |
| Regulation of actin polymerization or depolymerization | 5 | 0.0077 | 6.3 |
| Regulation of actin filament length | 5 | 0.0083 | 6.2 |
| Actin filament organization | 5 | 0.0114 | 5.7 |
| Regulation of actin filament polymerization | 4 | 0.0333 | 5.6 |
| Glial cell differentiation | 4 | 0.0392 | 5.3 |
| Regulation of actin filament-based process | 5 | 0.0153 | 5.2 |
| Regulation of cytoskeleton organization | 8 | 0.0009 | 5.1 |
| Regulation of cell migration | 7 | 0.0032 | 4.8 |
| Actin filament-based process | 11 | 0.0005 | 4.0 |
| Actin cytoskeleton organization | 10 | 0.0012 | 3.8 |
| Negative regulation of cell differentiation | 10 | 0.0023 | 3.5 |
| Positive regulation of cell proliferation | 12 | 0.0052 | 2.7 |
| Cell proliferation | 10 | 0.0160 | 2.6 |
| Cytoskeleton organization | 13 | 0.0054 | 2.5 |
| Regulation of cell proliferation | 18 | 0.0048 | 2.1 |
| Cell adhesion | 17 | 0.0154 | 1.9 |
Microarray analysis was used to identify 336 genes with FDR-corrected p value <0.05 and with 1.2-fold change cutoff. Note that oligodendrocyte differentiation and myelination, Wnt signaling pathway, and cytoskeleton regulation were significantly enriched as a result of oligodendroglial Apc disruption.