Table 1.

Time constants of Ca2+ and voltage gating obtained for BKCa channels in excised patches

Voltage gatingCa2+ gating
[Ca2+]iVoltage stepVm[Ca2+]i step
−80 to −50 mV (τON)−50 mV0 to [Ca2+]iON)
100    2.20 ± 0.23 (3)    1005.85 ± 1.08 (7)
10    3.10 ± 0.78 (6)    106.49 ± 0.50 (10)
3    4.18 ± 0.57 (8)    35.28 ± 0.72 (3)
100 to −50 mV (τOFF)100 μm to [Ca2+]iOFF)
1    0.76 ± 0.08 (4)    12.96 ± 0.28 (8)
0    0.47 ± 0.02 (3)    02.23 ± 0.57 (8)
−80 to 0 mV (τON)0 mV0 to [Ca2+]iON)
100    1.71 ± 0.11 (4)    1004.44 ± 0.88 (7)
10    1.72 ± 0.24 (9)    105.01 ± 1.90 (9)
3    6.13 ± 0.47 (8)    315.00 ± 1.09 (8)
100 to 0 mV (τOFF)100 μm to [Ca2+]iOFF)
1    3.77 ± 0.46 (10)    17.39 ± 1.07 (8)
0    0.86 ± 0.17 (8)    04.19 ± 1.06 (8)
−80 to 50 mV (τON)50 mV0 to [Ca2+]iON)
100    0.68 ± 0.09 (3)    1003.24 ± 1.03 (7)
10    1.09 ± 0.30 (7)    103.95 ± 0.68 (10)
3    5.56 ± 0.60 (8)    311.34 ± 3.05 (8)
114.57 ± 1.76 (9)    118.17 ± 2.01 (3)
100 to 50 mV (τOFF)100 μm to [Ca2+]iOFF)
0    3.28 ± 1.01 (4)    010.02 ± 3.29 (8)
  • All values are mean ± SEM of (n) experiments.