Table 4.

Sex-dependent influence on spontaneous nicotine withdrawal-induced deficits in cued fear conditioning^{^a}

	Chrna2^−/− nicotine		Chrna2^−/− saline		Chrna2^+/+ nicotine		Chrna2^+/+ saline
	Female	Male	Female	Male	Female	Male	Female	Male
Baseline	0.00 (2)	0.00 ± 0.00 (9)	0.00 ± 0.00 (3)	0.00 ± 0.00 (5)	0.00 ± 0.00 (6)	0.00 ± 0.00 (5)	0.00 (2)	0.00 ± 0.00 (8)
Immediate	0.00 (2)	0.22 ± 0.15 (9)	0.33 ± 0.33 (3)	0.60 ± 0.24 (5)	0.17 ± 0.17 (6)	0.60 ± 0.40 (5)	1.00 (2)	0.63 ± 0.32 (8)
Context	8.00 (2)	11.00 ± 1.34 (9)	9.67 ± 4.10 (3)	11.00 ± 1.70 (5)	8.50 ± 1.12 (6)	13.40 ± 2.64 (5)	10.00 (2)	12.63 ± 1.63 (8)
Pre-CS	0.50 (2)	0.22 ± 0.15 (9)	0.00 ± 0.00 (3)	0.00 ± 0.00 (5)	0.00 ± 0.00 (6)	0.00 ± 0.00 (5)	0.00 (2)	1.25 ± 0.49 (8)
CS	12.00 (2)	9.67 ± 0.67^* (9)	10.67 ± 1.67 (3)	12.40 ± 0.75 (5)	12.00 ± 2.00 (6)	9.80 ± 0.80 (5)	12.67 (2)	11.25 ± 0.65 (8)

↵^a Values represent number of freezing episodes and are presented as mean ± SEM (n).
↵*p < 0.05 versus Chrna2^−/− male saline-treated mice (uncorrected).