Table 1.

Comparison of pharmacological properties of NCGC84 with SHA68

Compound IDNCGC00185684NCGC00184846
Code nameNCGC84SHA68
StructureEmbedded ImageEmbedded Image
IC50 - cAMP22.1 ± 1.9208.3 ± 36.3
IC50 - Ca2+36.5 ± 6.4569.6 ± 130.3
IC50 - ERK-phospho9.3 ± 11.515.8 ± 2.7
IC50 - binding (95% CI)5.0 (3.88–6.42)9.5 (53.2–73.4)
pA2 (95% CI)8.98 (9.03–8.94)8.16 (8.25–8.08)
Schild slope1.03 ± 0.011.00 ± 0.03