Table 2.

Summary of functional analyses of 8×Ala replacement mutations

Replaced residuesSARM−/− rescue
410-417A (SAM1)−
445-452A (SAM1)−
481-488A (SAM2)−
517-524A (SAM2)+
625-632A (TIR)−
661-668A (TIR)−
697-704A (TIR)−
715-721A (post-TIR)+