Table 2.

Effects of ES and EB infusion of the MBH-ME region on release of GnRH and E2 in OVX female rhesus monkeys

Measured neurohormonesGnRHE2
TreatmentsES (N = 9)Sham ES (N = 9)ES (N = 9)Sham ES (N = 9)
ES
    Peak before (pg/ml)3.1 ± 0.42.9 ± 1.0242 ± 63 (5)*236 ± 37 (4)*
    Peak after (pg/ml)14.0 ± 2.7aaa,bbb3.3 ± 0.9437 ± 20a,b232 ± 72 (4)*
    Peak latency (min)24.4 ± 2.9a,ccc52.5 ± 10.064.4 ± 4.444.0 ± 8.4 (4)*
    Peak duration (min)42.2 ± 5.244.4 ± 7.337.8 ± 5.240.0 ± 8.2 (4)*
    IPI (min)66.7 ± 4.762.9 ± 8.164.0 ± 7.5 (5)*60.0 ± 8.2 (4)*
TreatmentsEB (N = 10)Vehicle (N = 10)EB (N = 10)Vehicle (N = 10)
EB
    Peak before (pg/ml)3.1 ± 0.43.7 ± 0.4281 ± 129 (5)*265 ± 80 (5)*
    Peak after (pg/ml)14.8 ± 4.3aa,bb3.3 ± 0.61285 ± 285a,b281 ± 53 (5)*
    Peak latency (min)26.0 ± 3.1aa58.0 ± 9.625.5 ± 2.8aa48.0 ± 4.9 (5)*
    Peak duration (min)38.0 ± 5.544.0 ± 5.832.0 ± 4.432.0 ± 3.3 (5)*
    IPI (min)62.0 ± 6.066.0 ± 5.070.0 ± 16.5 (8)*65.0 ± 12.6 (5)*
  • Data are mean ± SEM, N: Total number of experiments conducted. ()*: Number of experiments used for calculation; in some experiments sufficient E2 peaks were not present for calculation.

  • a p < 0.05;

  • aa p < 0.01;

  • aaa p < 0.001 versus vehicle or sham;

  • b p < 0.05;

  • bb p < 0.10;

  • bbb p < 0.001 versus mean before treatment;

  • ccc p < 0.001 versus E2.