Candidate regeneration genes tested by axotomy
| Gene | Allele | Molecular function/ortholog | % Regeneration | na | p |
|---|---|---|---|---|---|
| Wild-type | oxIs12 | 70 | 105 | ||
| No phenotype | |||||
| arr-1 | ok401 | β-Arrestin | 72 | 105 | 0.7613 |
| atf-6 | ok551 | ATF6 transcription factor | 65 | 75 | 0.628 |
| ccpp-1 | ok1821 | Cytosolic carboxypeptidase family | 71 | 97 | 1 |
| cdk-8 | tm1238 | CDK8 cyclin-dependent kinase | 60 | 55 | 0.2909 |
| ced-7 | n1996 | ABC transporter | 68 | 75 | 0.871 |
| ced-10 | n3246 | RAC1 GTPase | 61 | 66 | 0.2488 |
| cpx-1 | ok1552 | Complexin | 62 | 80 | 0.3477 |
| daf-18 | nr2037 | PTEN tumor suppresor; lipid phosphatase | 71 | 58 | 1 |
| dhc-1 | js319 | Dynein heavy chain | 54 | 67 | 0.051 |
| E02D9.1 | tm4000 | Predicted MAP2K | 76 | 66 | 0.4847 |
| ehs-1 | ok146 | Eps15 | 67 | 120 | 0.6697 |
| evl-9 | ar121 | Unknown | 83 | 24 | 0.2137 |
| evl-16 | ar93 | Unknown | 80 | 50 | 0.183 |
| evl-17 | ar94 | Unknown | 79 | 56 | 0.2669 |
| F32B5.1 | tm3359 | Arginine kinase | 70 | 64 | 1 |
| gska-3 | ok970 | Glycogen synthase kinase alpha subunit | 56 | 86 | 0.0698 |
| hrp-1 | ok963 | hnRNP A1 | 65 | 74 | 0.5212 |
| hmr-1b | zu389 | Neuronal cadherin | 62 | 76 | 0.3394 |
| kin-2 | ce179 | cAMP-dependent protein kinase subunit | 76 | 88 | 0.3344 |
| lin-7 | e1413 | LIN7 PDZ domain protein | 75 | 51 | 0.5757 |
| mir-2 | gk259 | MicroRNA | 60 | 57 | 0.2267 |
| mlp-1 | ok832 | Muscle LIM protein | 75 | 88 | 0.4247 |
| mtch-1 | ok1800 | Mitochondrial carrier homolog | 82 | 82 | 0.0813 |
| mtm-5 | ok469 | Myotubularin family | 63 | 91 | 0.3637 |
| nex-2 | bas4 | Annexin family | 79 | 76 | 0.1752 |
| nex-3 | gk385 | Annexin family | 76 | 104 | 0.3519 |
| nex-4 | gk102 | Annexin family | 69 | 138 | 1 |
| pct-1 | wy575 | Pctaire class cell cycle kinase | 79 | 57 | 0.267 |
| pek-1 | ok275 | PERK kinase | 63 | 89 | 0.2694 |
| ppfr-1 | tm2180 | Protein phosphatase four regulatory subunit | 63 | 56 | 0.3834 |
| ptl-1 | ok621 | Tau-like; microtubule binding protein | 75 | 76 | 0.5037 |
| sir-2.1 | ok434 | Yeast SIR2-like | 84 | 61 | 0.0632 |
| snb-1 | js124 | Synaptobrevin | 79 | 105 | 0.155 |
| snt-1 | md290 | Synaptotagmin | 76 | 62 | 0.4767 |
| snt-2 | tm1711 | Synaptotagmin | 63 | 101 | 0.378 |
| snt-3 | tm2426 | Synaptotagmin | 70 | 81 | 1 |
| snt-4 | ok503 | Synaptotagmin | 76 | 93 | 0.338 |
| snt-6 | tm3686 | Synaptotagmin | 56 | 81 | 0.0652 |
| sta-1 | ok587 | STAT transcription factor family | 75 | 71 | 0.4991 |
| tom-1 | ok285 | Tomosyn | 74 | 54 | 0.5848 |
| unc-59 | e261 | Septin | 73 | 102 | 0.6489 |
| wwp-1 | gk372 | NEDD4-like E3 ubiquitin ligase | 70 | 88 | 1 |
| Improved growth cone formation | |||||
| atfs-1 | gk3094 | ATF transcription factor | 95 | 75 | <0.0001 |
| cdka-1 | tm648 | CDK5 cyclin dependent kinase | 84 | 77 | 0.023 |
| daf-2 | e1370 | Insulin/IGF Receptor | 89 | 82 | 0.0013 |
| hst-3.1 | tm734 | Heparan Sulphotransferase | 83 | 78 | 0.0376 |
| kal-1 | gb503 | KAL1; mutated in Kallmann syndrome | 82 | 115 | 0.0405 |
| lin-10 | sy217 | Mint; PDZ domain protein | 90 | 59 | 0.0035 |
| mpk-1 | ga119 | MAP kinase | 96 | 46 | 0.0002 |
| ric-4 | ok173 | SNAP25 | 95 | 88 | <0.0001 |
| snt-5 | ok3287 | Synaptotagmin | 92 | 84 | 0.0002 |
| unc-26 | s1710 | Synaptojanin | 95 | 65 | <0.0001 |
| unc-57 | ok310 | Endophilin | 96 | 75 | <0.0001 |
| unc-104 | e1265 | Synaptic vesicle kinesin | 94 | 62 | 0.0002 |
| unc-116 | e2310 | Kinesin heavy chain | 89 | 72 | 0.0031 |
| Reduced growth cone formation | |||||
| aak-2 | gt33 | AMP-activated kinase | 53 | 72 | 0.0148 |
| daf-16 | m26 | FOXO transcription factor | 27 | 59 | <0.0001 |
| mtm-6 | ok330 | Myotubularin family | 26 | 106 | <0.0001 |
| mtm-9 | ar479 | Myotubularin family | 44 | 91 | 0.0005 |
| nex-1 | gk148 | Annexin family | 39 | 105 | <0.0001 |
| psr-1 | ok714 | Phosphatidylserine receptor | 46 | 91 | 0.0013 |
| stau-1 | tm2266 | Staufen; dsRNA-binding protein | 46 | 87 | 0.0012 |
| unc-33 | e204 | CRMP; collapsin response mediator protein | 50 | 50 | 0.0214 |
| unc-129 | ev557 | TGFβ family secreted growth factor | 25 | 102 | <0.0001 |
↵aNumber of axotomized axons.