Basal body temperature, nociception, and open field activity is normal in S426A/S430A mutants
| Mice | Baseline tail-flick (s) | Body temperature (°C) | Spontaneous activity (cm) | Habituated activity (cm) |
|---|---|---|---|---|
| WT | 3.01 ± 0.09 | 37.9 ± 0.1 | 4331 ± 361 | 744 ± 160 |
| S426A/S430A | 3.34 ± 0.12 | 38.1 ± 0.1 | 3867 ± 376 | 855 ± 289 |
Data are presented as the averages ± SEM and were analyzed using unpaired Student's t test. No significant differences were found between the genotypes. Basal body temperature and baseline tail-flick response activity were measured in 49 S426A/S430A mutant and 55 WT mice. Spontaneous and habituated locomotor activity was examined in 12 S426A/S430A mutant and 17 WT mice.