Intrinsic membrane properties and AP characteristics measured in WT and Nav1.9−/− mouse myenteric neurons
| WT mice | Nav1.9−/− mice | p | |||
|---|---|---|---|---|---|
| Mean ± SEM | n | Mean ± SEM | n | ||
| Membrane capacitance (pF) | 14.5 ± 1.3 | 17 | 13.2 ± 1.8 | 10 | 0.55 |
| Input resistance (MΩ) | 576 ± 40 | 17 | 675 ± 75 | 10 | 0.21 |
| Holding membrane potential (mV) | −78.2 ± 0.9 | 17 | −75.7 ± 1.9 | 10 | 0.18 |
| Holding current (pA) | −71 ± 17 | 17 | −78 ± 12 | 10 | 0.73 |
| Current threshold (pA/pF) | 9.4 ± 1.7 | 9 | 10.0 ± 1.1 | 10 | 0.76 |
| AP threshold (mV) | −24.9 ± 1.1 | 17 | −22.1 ± 1.1 | 10 | 0.11 |
| AP overshoot (mV) | 44.6 ± 5 | 17 | 38.6 ± 4.8 | 10 | 0.43 |
| AP half-width (ms) | 1.59 ± 0.07 | 17 | 1.09 ± 0.09 | 10 | 0.0001 |
| AHP amplitude (mV) | −11.1 ± 2.1 | 11 | 4.1 ± 2.3 | 9 | 0.0009 |
Statistical comparisons were made applying the Student's t test for unpaired data.