Table 1.

Monoamines and their metabolites in the striatuma

Content or ratioLmtk3+/+Lmtk3−/−
NE3.08 ± 0.364.01 ± 1.08
DA666.52 ± 25.41667.30 ± 21.30
DOPAC38.40 ± 1.0344.18 ± 1.99*
HVA52.26 ± 2.2259.24 ± 2.48*
3-MT27.86 ± 0.8532.14 ± 1.30*
(DOPAC + HVA + 3-MT)/DA0.179 ± 0.0050.204 ± 0.006**
5-HT22.99 ± 1.2123.03 ± 1.51
5-HIAA14.53 ± 0.8915.12 ± 0.94
5-HIAA/5-HT0.640 ± 0.0350.669 ± 0.035
  • aThe values of neurochemical are shown as pmol/mg of protein (mean ± SEM; n = 14). The turnovers of metabolites are shown as the ratio of the neurochemicals. NE, Norepinephrine; DA, dopamine.

  • *p < 0.05, compared with wild-type control.

  • **p < 0.01, compared with wild-type control.