Table 1.

Statistical analysis of noradrenaline concentrations in 4- and 12-month-old mice (see Fig. 1C,D)

ComparisonBrain area4 month p valuea12 month p valuea
wt vs APP/PS1OBn.s.<0.01
FCn.s.<0.01
HCn.s.<0.05
CBn.s.<0.05
wt vs Ear2(−/−)OB<0.001<0.001
FC<0.001<0.001
HC<0.001<0.001
CB<0.001<0.001
wt vs APP/PS1/Ear2(−/−)OB<0.001<0.001
FC<0.001<0.001
HC<0.001<0.001
CB<0.001<0.001
APP/PS1 vs Ear2(−/−)OB<0.001<0.001
FC<0.001<0.001
HC<0.001<0.001
CB<0.001<0.001
APP/PS1 vs APP/PS1/Ear2(−/−)OB<0.001<0.001
FC<0.001<0.001
HC<0.001<0.001
CB<0.001<0.001
Ear2(−/−) vs APP/PS1/Ear2(−/−)OBn.s.n.s.
FCn.s.n.s.
HCn.s.n.s.
CBn.s.n.s.
  • aTwo-way ANOVA followed by Bonferroni's post hoc test.

  • OB, Olfactory bulb; FC, frontal cortex; HC, hippocampus; CB, cerebellum.