Table 1.

Synaptic alterations in Htt cKO and zQ175 mice^{^a}

	Synapse number		Spine maturation
	cKO versus Control	zQ175 versus WT	cKO versus Control	zQ175 versus WT
P21
Cortex	↑ (1.5-fold)	↑ (1.5-fold)	Layer 5 ↑	Layer 5 ↑
Striatum	C-S↑	C-S^*	↑	↑
	T-S^*	T-S^*
5 weeks
Cortex	^* (trending ↓)	n.s.	Layer 5 ↓	Layer 5 ↓
Striatum	C-S ↑	C-S^*	↑	↓
	T-S↑	T-S ↓

↵^aC-S, Corticostriatal; T-S, thalamostriatal; ↑, increase; ↓, decrease.
↵*No significant change.