Table 2.

Group differences in the frontal speech production tracts for all DTI metrics

Frontal tractsDTI metrics
HCNfvPPApSvPPApLvPPAp
BA44-SMAc
    Left
        FA0.374 (0.019)0.324 (0.028)*,b,c0.0000.368 (0.036)0.950.371 (0.024)0.99
        MD0.600 (0.021)0.677 (0.037)*,b,c0.0000.631 (0.039)0.080.630 (0.024)0.07
        AD0.861 (0.024)0.924 (0.040)*0.0000.900 (0.045)0.080.893 (0.022)0.07
        RD0.472 (0.024)0.552 (0.038)*,b,c0.0000.479 (0.043)0.200.496 (0.030)0.24
    Right
        FA0.380 (0.025)0.341 (0.031)0.0050.369 (0.03)0.750.383 (0.023)0.99
        MD0.587 (0.020)0.637 (0.042)*0.0000.617 (0.026)0.070.598 (0.030)0.79
        AD0.844 (0.021)0.877 (0.045)0.380.878 (0.025)0.060.860 (0.036)0.56
        RD0.458 (0.024)0.516 (0.043)*,c0.0000.487 (0.034)0.120.466 (0.032)0.93
BA6vPMC-SMAc
    Left
        FA0.384 (0.022)0.331 (0.035)*,b,c0.0000.382 (0.032)0.990.378 (0.029)0.95
        MD0.602 (0.018)0.668 (0.051)*,b,c0.0000.616 (0.032)0.670.614 (0.027)0.77
        AD0.850 (0.020)0.915 (0.046)*0.0000.891 (0.043)0.020.878 (0.028)0.16
        RD0.458 (0.024)0.542 (0.054)*,b,c0.0000.477 (0.031)0.550.482 (0.031)0.34
    Right
        FA0.393 (0.028)0.359 (0.027)0.010.386 (0.031)0.920.397 (0.020)0.98
        MD0.579 (0.022)0.639 (0.040)*0.0000.609 (0.030)0.060.590 (0.027)0.77
        AD0.839 (0.025)0.900 (0.049)*0.0000.884 (0.029)0.010.856 (0.032)0.59
        RD0.446 (0.026)0.509 (0.041)*0.0000.473 (0.033)0.160.453 (0.028)0.95
BA44-Caudate
    Left
        FA0.324 (0.019)0.292 (0.030)0.010.305 (0.027)0.250.303 (0.028)0.20
        MD0.628 (0.018)0.710 (0.036)*0.0000.672 (0.057)0.010.653 (0.035)0.26
        AD0.855 (0.021)0.937 (0.040)*0.0000.901 (0.059)0.020.880 (0.033)0.34
        RD0.512 (0.021)0.591 (0.041)*0.0000.559 (0.059)0.010.540 (0.035)0.24
    Right
        FA0.335 (0.023)0.310 (0.023)0.040.319 (0.027)0.370.342 (0.017)0.87
        MD0.608 (0.020)0.657 (0.037)*0.0000.631 (0.029)0.160.620 (0.024)0.67
        AD0.834 (0.019)0.888 (0.047)*0.0000.862 (0.040)0.130.855 (0.028)0.34
        RD0.493 (0.022)0.540 (0.035)*0.0000.515 (0.032)0.210.499 (0.024)0.95
BA44-Putamen
    Left
        FA0.306 (0.019)0.273 (0.016)*0.0010.286 (0.029)0.100.292 (0.022)0.37
        MD0.633 (0.019)0.701 (0.033)*,c0.0000.668 (0.040)0.030.662 (0.036)0.09
        AD0.860 (0.023)0.918 (0.034)*,b0.0000.877 (0.028)0.470.886 (0.039)0.14
        RD0.523 (0.019)0.593 (0.032)*,c0.0000.560 (0.043)0.030.552 (0.035)0.08
    Right
        FA0.291 (0.018)0.273 (0.016)0.330.286 (0.029)0.440.292 (0.022)0.90
        MD0.623 (0.021)0.652 (0.031)0.020.637 (0.026)0.480.636 (0.023)0.58
        AD0.834 (0.024)0.857 (0.032)0.140.835 (0.025)0.990.850 (0.026)0.45
        RD0.517 (0.020)0.549 (0.030)0.010.536 (0.031)0.250.522 (0.027)0.95
BA6vPMC-Caudate
    Left
        FA0.363 (0.027)0.333 (0.016)0.010.369 (0.017)0.900.375 (0.023)0.61
        MD0.591 (0.019)0.674 (0.043)*0.0000.607 (0.033)0.580.612 (0.028)0.31
        AD0.828 (0.021)0.928 (0.061)*0.0000.862 (0.058)0.170.878 (0.032)0.02
        RD0.473 (0.023)0.543 (0.037)*0.0000.478 (0.024)0.960.488 (0.026)0.51
    Right
        FA0.344 (0.019)0.332 (0.018)0.450.342 (0.027)0.990.349 (0.022)0.96
        MD0.599 (0.018)0.654 (0.041)*0.0000.620 (0.029)0.220.608 (0.026)0.83
        AD0.822 (0.017)0.899 (0.058)*0.0000.856 (0.049)0.110.846 (0.029)0.40
        RD0.481 (0.021)0.533 (0.036)*0.0000.499 (0.030)0.370.488 (0.026)0.92
BA6vPMC-Putamen
    Left
        FA0.299 (0.027)0.265 (0.025)0.0050.300 (0.020)1.000.297 (0.019)0.99
        MD0.629 (0.022)0.687 (0.036)*0.0000.632 (0.033)0.990.648 (0.036)0.44
        AD0.849 (0.029)0.897 (0.029)0.0020.851 (0.029)0.990.871 (0.040)0.33
        RD0.519 (0.024)0.581 (0.041)*0.0000.525 (0.032)0.950.536 (0.03)0.54
    Right
        FA0.321 (0.016)0.303 (0.026)0.200.315 (0.027)0.920.326 (0.028)0.94
        MD0.619 (0.023)0.650 (0.030)0.030.628 (0.025)0.860.623 (0.035)0.99
        AD0.844 (0.029)0.870 (0.030)0.130.850 (0.031)0.950.857 (0.029)0.68
        RD0.500 (0.017)0.533 (0.030)0.010.516 (0.028)0.420.507 (0.034)0.92
SMAc-Caudate
    Left
        FA0.364 (0.028)0.306 (0.032)*,b0.0000.346 (0.037)0.480.338 (0.027)0.17
        MD0.610 (0.020)0.698 (0.050)*,b,c0.0000.646 (0.046)0.060.641 (0.027)0.10
        AD0.865 (0.021)0.940 (0.056)*,c0.0000.904 (0.045)0.060.893 (0.023)0.23
        RD0.481 (0.027)0.576 (0.050)*,b,c0.0000.517 (0.051)0.090.515 (0.032)0.12
    Right
        FA0.352 (0.025)0.304 (0.020)*,c0.0000.327(0.029)0.070.345 (0.023)0.90
        MD0.613 (0.020)0.678 (0.043)*,c0.0000.641 (0.029)0.090.625 (0.025)0.71
        AD0.862 (0.019)0.916 (0.048)*0.0000.889 (0.026)0.120.880 (0.032)0.45
        RD0.486 (0.026)0.559 (0.042)*,b,c0.0000.518 (0.035)0.080.500 (0.028)0.71
SMAc-Putamen
    Left
        FA0.337 (0.025)0.308 (0.036)0.010.350 (0.038)0.740.334 (0.033)0.99
        MD0.608 (0.021)0.678 (0.040)*,b,c0.0000.631 (0.041)0.270.637 (0.030)0.10
        AD0.847 (0.021)0.925 (0.034)*,c0.0000.889 (0.041)0.0030.887 (0.022)0.01
        RD0.486 (0.026)0.555 (0.046)*,b0.0000.501 (0.046)0.760.512 (0.036)0.31
    Right
        FA0.356 (0.029)0.325 (0.027)0.040.354 (0.033)0.990.359 (0.023)0.99
        MD0.591 (0.019)0.647 (0.037)*0.0000.614 (0.031)0.190.604 (0.028)0.67
        AD0.836 (0.021)0.889 (0.037)*0.0000.864 (0.030)0.080.861 (0.032)0.14
        RD0.464 (0.025)0.524 (0.042)*0.0000.488 (0.036)0.270.475 (0.031)0.84
SMAc-Insula
    Left
        FA0.370 (0.030)0.342 (0.038)0.180.400 (0.039)0.100.377 (0.032)0.98
        MD0.600 (0.022)0.674 (0.040)*0.0000.624 (0.039)0.280.630 (0.026)0.05
        AD0.861 (0.027)0.942 (0.045)*0.0000.918 (0.050)0.0040.902 (0.023)0.03
        RD0.470 (0.028)0.543 (0.042)*0.0000.479 (0.041)0.980.491 (0.035)0.36
    Right
        FA0.367 (0.039)0.340 (0.035)0.140.381 (0.035)0.620.375 (0.028)0.90
        MD0.587 (0.019)0.642 (0.044)*0.0000.614 (0.035)0.110.600 (0.033)0.42
        AD0.843 (0.030)0.900 (0.047)0.0030.887 (0.031)0.010.864 (0.041)0.12
        RD0.458 (0.023)0.514 (0.045)*0.0000.476 (0.036)0.610.464 (0.033)0.90
BA44-Insula
    Left
        FA0.297 (0.021)0.261 (0.021)0.0030.280 (0.027)0.350.292 (0.021)0.94
        MD0.639 (0.020)0.702 (0.033)*0.0000.675 (0.040)0.050.660 (0.035)0.25
        AD0.867 (0.024)0.912 (0.032)0.0040.890 (0.034)0.400.885 (0.039)0.34
        RD0.531 (0.020)0.600 (0.034)*0.0000.569 (0.041)0.030.551 (0.033)0.25
    Right
        FA0.295 (0.021)0.275 (0.025)0.210.284 (0.019)0.400.301(0.019)0.99
        MD0.626 (0.020)0.658 (0.035)0.020.640 (0.019)0.380.638 (0.022)0.43
        AD0.841 (0.021)0.860 (0.032)0.240.848 (0.022)0.940.859 (0.020)0.30
        RD0.521 (0.023)0.559(0.038)0.020.536 (0.022)0.420.525 (0.026)0.86
BA6vPMC-Insula
    Left
        FA0.299 (0.023)0.266 (0.029)0.0050.307 (0.015)0.770.298 (0.016)0.99
        MD0.640 (0.018)0.690 (0.035)*0.0000.648 (0.031)0.820.662 (0.022)0.13
        AD0.862 (0.024)0.900 (0.035)0.030.866 (0.030)0.930.887 (0.034)0.05
        RD0.529 (0.022)0.587 (0.038)*0.0000.537 (0.027)0.920.550 (0.022)0.25
    Right
        FA0.317 (0.018)0.288 (0.025)0.020.312 (0.024)0.900.317 (0.029)0.98
        MD0.637 (0.020)0.662 (0.031)0.160.642 (0.021)0.910.643 (0.035)0.77
        AD0.863 (0.026)0.873 (0.029)0.950.865 (0.024)0.510.874 (0.030)0.97
        RD0.522 (0.017)0.556 (0.034)0.030.529 (0.025)0.880.527 (0.036)0.83
  • MD, AD, and RD values are reported as mean (SD) in mm2/s × 10−3.

  • *Significant differences between PPA variants and healthy controls at p < 0.002 (Bonferroni adjusted).

  • an Significant differences from nonfluent variants at p < 0.05.

  • bn Significant differences from semantic variants at p < 0.05.

  • cn Significant differences from logopenic variants at p < 0.05.