ago, Agonist; ant, antagonist.
The occurrence of all off-nest behaviors was scored for 60 min before and for 90 min after infusion (indicated by the dotted line). Off-nest behavior is further divided into locomotion (including digging/burrowing and any explorative behavior in the home cage), self-grooming, and sleeping/resting. For details on treatments, see legend to Figure 1. Data are presented as mean ± SEM. n = 6–7 per group.
*p ≤ 0.05 versus VEH; +p ≤ 0.05 versus previous time point (two-way ANOVA for repeated measures; factors: time × treatment);
##p ≤ 0.01 versus VEH (two-way ANOVA for repeated measures; factor: treatment).