Table 2.

Sirt1 and indicated Sirt1-targeted genes in brains of IRF9-KO mice compared with WT control^{^a}

Sirt1 targets	Transcript ID	Symbol	Log2 ratio (case/control)
Sirt1	NM_019812	Sirt1	2.135
Proliferation and growth	NM_008117	Gh	2.574
	NM_008709	MYCN	1.558
	NM_007415	PARP1	2.976
Cell-cycle arrest and apoptosis	NM_007527	BAX	−1.69
	NM_007609	CASP4	−1.834
	NM_007656	CD82	−1.741
	NM_007833	DCN	−1.465
	NM_010107	EFNA1	−1.494
	NM_019740	FOXO3	−1.552
	NM_008655	GADD45B	−1.697
	NM_001037713	XAF1	−3.031
Neuronal formation and function	NM_007913	EGR1	1.508
	NM_008882	PLXNA2	1.811
	NM_001111015	SYN2	1.401
Immune response and inflammation	NM_011888	CCL19	−1.769
	NM_011611	CD40	−1.423
	NM_021274	CXCL10	−5.304
	NM_011163	EIF2AK2	−2.062
	NM_010260	Gbp2	−3.44
	NM_001111282	HMGB1	−1.564
	NM_001033450	Ifi204	−5.145
	NM_027835	IFIH1	−1.674
	NM_008361	IL1B	−3.019
	NM_031168	IL6	−2.724
	NM_016850	IRF7	−2.006
	NM_001113527	ISG20	−1.553
	NM_008605	MMP12	−1.99
	NM_019401	NMI	−1.508
	NM_016764	PRDX4	−1.59
	NM_009283	STAT1	−1.595
Other	NM_010856	Myh6	5.259
	NM_001111279	Wdfy1	4.47
	NM_053200	Ces3	−3.621
	NM_019697	Kcnd2	−1.99

↵^aIRF9 ablation alters the expressions of Sirt1-targeted genes. Log2 ratio of mRNA levels of Sirt1 and indicated Sirt1-targeted genes in brains of IRF9-KO mice compared with WT control, as determined by three independent mRNA microarray experiments.