Table 1.

Gating parameters of Kv4 channels

Standard whole-cellWT (n = 9)A53T (n = 8)p
Steady-state activation Kv4 (mV)
    V50−28.8 ± 0.8−30.8 ± 0.5ns
    Slope factor5.9 ± 0.76.0 ± 0.2ns
Steady-state inactivation Kv4 (mV)(n = 14)(n = 11)ns
    V50−61.4 ± 0.6−60.0 ± 0.8ns
    Slope factor5.3 ± 0.35.0 ± 0.3ns
Nucleated outside-out(n = 6)(n = 4)ns
Tau-inactivation@ −30 mV (ms)13.8 ± 1.313.1 ± 0.9ns
Tau-recovery@ −80 ms (ms)9.8 ± 0.210.9 ± 0.9ns