Table 2.

Regions with a significant increase in fMRI signal for increasing prospective losses at the time of incentive presentation (p < 0.001, uncorrected)

Brain region	Laterality	Peak Talairach coordinates (mm)			Peak t value
Brain region	Laterality	x	y	z	Peak t value
Striatum (nucleus accumbens, ventral putamen)^*	R	12	11	−8	5.10
Striatum (nucleus accumbens, ventral putamen)^*	L	−15	8	−8	5.08
Caudate	L	−21	−91	4	6.45
Supplementary motor area	R	9	11	43	5.32
Insula	L	−54	−37	22	4.94
Dorsolateral prefrontal cortex	R	33	26	4	4.86
Cerebellum	L	−45	−61	−23	4.72
Parietal cortex	R	60	−40	40	4.67
Premotor cortex	L	−48	−4	46	4.67
Midbrain	C	0	−28	−2	4.49
Posterior cingulate	R	21	−43	23	4.12
Temporal cortex	R	42	−58	−17	4.05

↵At the time of incentive presentation, no regions showed decreasing activity for increasing prospective losses. Statistically significant activations are those found in a priori regions of interest (familywise error, *p < 0.05) and those regions that survive whole-brain correction for multiple comparisons (at *p < 0.05). Laterality - right (R); left (L); central (C).